Member of the Technical Staff, Molecular Generation
About the role
Output has built a biological reasoning model that understands biology at the scale and complexity life actually operates. Our model independently learned the principles of molecular interactions, opening up drug treatments that were previously impossible. We're already generating therapies that traditional approaches cannot reach. The hardest problems in both AI and biology are being solved here, and there is room for you to own one.
Output is currently in stealth, operated by a team of repeat founders and biotech veterans with multiple exits in AI x Bio, and backed by top-tier VCs including Y Combinator.
You will lead the design and development of Output's generative models, working across molecular modalities to build systems that produce novel, biologically grounded molecules. This role spans the full arc from research to trained model: you design architectures, develop training approaches, run experiments on distributed GPU clusters, and evaluate results.
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You will design and build generative architectures for molecular data spanning multiple modalities, including small molecules, peptides, mini proteins and more
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You will develop training approaches that learn from diverse biological signal, ensuring the model composes genuinely novel structures
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You will build methods for controllable, targeted generation, enabling the model to produce molecules with specified biological properties while satisfying real-world chemical constraints
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You will integrate biological reasoning from our foundation model into the generative pipeline, using learned biological representations to guide and condition generation
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You will own training end-to-end: experiment design, distributed training on multi-GPU clusters, hyperparameter optimization, and iteration
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You will design evaluation frameworks that go beyond statistical metrics to measure whether generated molecules are biologically meaningful, structurally valid, and genuinely novel
