Director, Office of the CEO, Founder in Residence Program

The ideal candidate is a first-principles thinker, a builder, AI-native, and exceptionally sharp. You have founded a company, operated at the most senior level of a top scaleup, or built a track record of high-impact strategic work, and you are looking for your next high-leverage seat — one that gives you scale, mission, and direct CEO exposure without starting from scratch.

This role is a hybrid (onsite 3 days/week) position and reports directly to the VP of Business Operations and Chief of Staff, with active co-sponsorship from the CEO.

Responsibilities:

• Own CEO-Priority Projects: Lead one or more of BillionToOne's highest-priority strategic and operational initiatives each quarter, sourced directly from the CEO and Office of the CEO. Project types span new product launch support, commercial and go-to-market strategy, business development, operational excellence, competitive response, and the incubation of new business lines.
• Find Broken Things and Fix Them: Identify under-performing processes, workflows, or functions. Diagnose root cause, design the fix, and drive execution end-to-end with cross-functional teams.
• Cross-Functional Leadership: Lead and influence cross-functional teams across Sales, Product, Lab Operations, Compliance, Reimbursement, Finance, BD, Legal, and HR. Build deep working knowledge of how each function operates through the projects you lead.
• Operate with AI: Drive results in ambiguous, fast-moving environments. Use first-principles thinking and AI-native fluency to move faster than the company would otherwise be able to.
• CEO and Executive Partnership: Participate in CEO meetings, present to the executive team on an ongoing basis, and serve as a trusted thought partner to the CEO and Chief of Staff on company-shaping decisions.

Qualifications:

• 6-10+ years of building or operating experience, with a track record of exceptional impact in entrepreneurial or builder-oriented environments
• One of the following backgrounds: founder of a company that has since been acquired, wound down, or moved on from; senior executive (COO, CPO, VP-level) who joined a top scaleup as one of its first 5 to 10 employees; or top-tier management consultant from MBB or a top boutique firm with healthcare or life sciences exposure, with some operational experience under your belt. 
• First-principles thinker with exceptional analytical horsepower
• Builder mentality — bias to action, comfort with ambiguity, ability to operate without a playbook
• AI-native fluency in using AI tools to move faster and amplify individual leverage
• Strong written and verbal communication, including with executives and the Board
• Genuine interest in molecular diagnostics and the BillionToOne mission
• On-site position (relocation to SF Bay Area required)

Nice-To-Haves:

• Prior exposure to healthcare, life sciences, molecular diagnostics, or other regulated industries
• Track record of building 0 to 1 — new products, new functions, new business lines, or new operating mechanisms
• Existing network in the founder community, YC ecosystem, or top scaleup operating community

Benefits And Perks:

• Working alongside brilliant, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousands of patients
• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
• Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
• Supplemental fertility benefits coverage
• Retirement savings program including a 4% Company match
• Increased paid time off with increased tenure
• Latest and greatest hardware (laptop, lab equipment, facilities)
• Free daily on-site lunches provided from top eateries
• A variety of perks on campus (state of the art gym, restaurant)
• Free on-site EV charging (compatible with all EVs, including Tesla)

A meeting lands on your calendar

If they’re a yes, I book the chat. You show up — that’s the whole job-hunt.