About the role
Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies. Position Manifold Bio is seeking a scientist experienced in protein chemistry, oligonucleotide chemistry, and bioconjugation. You will be responsible for designing and executing bioconjugation strategies for protein-oligonucleotide conjugates, as well as bioconjugated fluorophores, tags, and peptides. In addition to performing, optimizing, and troubleshooting bioconjugation in the lab, you will oversee contract research organizations executing specialized or large-scale bioconjugation projects. You will consistently execute core bioconjugation protocols, proactively contribute to workflow optimization, and bring your excitement for rigorous science and troubleshooting to our growing cross-functional team. You will join a team with deep experience in protein chemistry, RNA biology, and biology, and work closely with a highly interdisciplinary team of creative experimental and computational scientists to advance our tissue-targeted oligomedicines pipeline.
Responsibilities Design, execute, and troubleshoot bioconjugation reactions for protein-oligonucleotide conjugates and other bioconjugated fluorophores, tags, and peptides Purify and characterize bioconjugated products using standard biochemical techniques Build and maintain a parallelized, efficient workflow to support in vivo target engagement evaluation of multiple new candidate tissue-targeting shuttles using tool siRNA payloads Oversee contract research organizations (CROs) performing specialized or large-scale bioconjugation projects Proactively identify and drive optimization of existing bioconjugation and analytical workflows Maintain accurate, detailed experimental records and contribute to scientific discussions and experimental design Required
