Senior Director, Business Development

The role requires exceptional scientific acumen, strong financial and strategic analysis capabilities, and outstanding transaction execution skills. The successful candidate will help shape Cabaletta's long-term growth strategy by identifying innovative technologies and assets that complement the company's mission of developing curative targeted cell therapies for autoimmune disease.

Responsibilities Include Business Development Strategy Identify and evaluate external opportunities including licensing, acquisitions, strategic collaborations, platform technologies, and co-development partnerships. Continuously assess the competitive landscape to identify emerging scientific and commercial opportunities aligned with Cabaletta's strategic priorities, including product expansion, geographic expansion, and lifecycle management strategies. Develop business development strategies that support both near-term pipeline expansion and long-term platform growth. Monitor industry trends, emerging technologies, financing activity, and M&A transactions to inform corporate decision-making. Opportunity Assessment Lead scientific, clinical, commercial, operational, intellectual property, and financial diligence for potential transactions. Build integrated commercial and financial models to evaluate strategic fit, market opportunity, probability-adjusted value, and return on investment. Prepare investment recommendations and executive-level presentations for the Executive Leadership Team and Board of Directors. Transaction Leadership Lead cross-functional transaction teams through all phases of partnering activities. Coordinate diligence efforts across Research, Clinical Development, Regulatory, CMC, Manufacturing, Commercial, Finance, Legal, and Intellectual Property. Support negotiation of confidentiality agreements, term sheets, licensing agreements, collaboration agreements, acquisition documents, and related contracts. External Relationship Management Develop and maintain relationships with biotechnology companies, academic institutions, CDMOs and potential strategic partners. Represent Cabaletta at major partnering, investor and scientific/medical conferences along with at industry meetings. Build a broad network across autoimmune disease, cell therapy, gene editing, in vivo engineering, and immunology ecosystems. Alliance Management Serve as the primary business lead for strategic collaborations and licensing partnerships following transaction execution, ensuring alignment with Cabaletta's strategic and operational objectives. Build and maintain productive relationships with external partners, fostering transparency, trust, and effective governance throughout the lifecycle of each alliance. Participate / co-lead in Joint Steering Committees (JSCs), Joint Development Committees (JDCs), and other governance bodies, coordinating internal cross-functional participation and decision-making. Monitor alliance performance, contractual obligations, key milestones, financial commitments, and governance deliverables to ensure successful execution of partnership objectives. Collaborate closely with Research, Clinical Development, Technical Operations, Regulatory, Commercial, Finance, Legal, and Executive Leadership to proactively identify and resolve issues that may impact partnership success. Support amendments, expansions, and new strategic opportunities within existing collaborations, identifying ways to maximize long-term value for both Cabaletta and its partners. Ensure effective communication between internal stakeholders and external collaborators while serving as a trusted ambassador for Cabaletta in all partnership interactions. Required

Qualifications Advanced scientific or business degree preferred (PhD, MD, PharmD, MBA, or equivalent). Bachelor's degree in life sciences, business, finance, or related discipline required. 10+ years of progressive experience in biotechnology, pharmaceuticals, management consulting, corporate strategy, or business development. Demonstrated experience leading licensing transactions, strategic collaborations, acquisitions, governance committees, cross-company collaborations following transaction execution, and corporate development initiatives. Strong understanding of biologics, cell therapy, gene therapy, immunology, and autoimmune disease drug development. Excellent financial modeling, valuation, strategic analysis, and commercial assessment skills. Experience performing multidisciplinary diligence across scientific, clinical, regulatory, manufacturing, commercial, legal, and financial domains. Outstanding executive communication and presentation skills with demonstrated ability to influence senior leadership. Proven ability to manage multiple high-priority initiatives in a fast-paced, entrepreneurial environment. Willingness to travel domestically and internationally as needed. Preferred

Qualifications Experience in cell therapy, gene therapy, CAR-T, autoimmune disease, or rare disease. Prior experience executing licensing or M&A transactions. Existing network across biotechnology companies, venture investors, academic innovators, and strategic pharmaceutical partners. Experience supporting Board of Directors materials and Executive Leadership strategic planning. Familiarity with valuation methodologies, portfolio prioritization, and corporate finance principles. What You'll Bring Strategic curiosity and a passion for identifying transformative scientific opportunities. Strong business judgment balanced with scientific rigor. Exceptional relationship-building and negotiation skills. Entrepreneurial mindset with the ability to work independently while collaborating across diverse teams. Commitment to Cabaletta's mission of delivering potentially curative therapies for patients with autoimmune disease. Our name – Cabaletta – is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression. For more information, please visit https://www.cabalettabio.com/join-our-crew Our most important asset is our people, and we offer competitive

benefits, PTO, and stock option plans. Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or

compensation. And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm. #LI-HYBRID Apply for this job First name Last name Email address Location Phone number Resume Attach resume Attach another file Attach file Add another What are your salary

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