About the role
Associate Scientist, Display Technologies Department: Lab Science Employment Type: Full Time Location: San Mateo, CA Description
The role: BigHat Biosciences is seeking a curious and motivated Associate Scientist to join the Display Technologies team. This individual will contribute to BigHat’s antibody discovery and engineering efforts and help generate high-quality data to improve BigHat’s machine learning models using display technologies, working closely with senior scientists and cross-functional teams. *At BigHat we believe in titles that commensurate with skill set, relative organizational impact, and value contribution; more experienced candidates are encouraged to apply, with the understanding that
responsibilities and title would adjust as appropriate. Key
Responsibilities Support R&D projects advancing display technologies at BigHat that expands BigHat's antibody discovery capabilities and feed its ML models. Lead in the construction and QC of phage and yeast display libraries across diverse antibody formats (VHH, scFv, Fab) using standard molecular biology techniques (PCR, molecular cloning, electroporation). Execute phage and yeast display selections using naive and affinity and stability maturation libraries to discover and engineer antibodies with desired therapeutic properties. Express, purify, and characterize display-derived molecules using assays including ELISA, flow cytometry, BLI/SPR, CE-SDS, and others. Analyze selection results and contribute to discussions on next steps and future experimental design. Collaborate with BigHat’s Data Science and Machine Learning teams to inform library design and interpret selection data for model training. Present experimental plans and results during regular meetings with manager and science teams. Maintain thorough records using LIMS and electronic notebooks. Skills Knowledge and Expertise BS or MS in Biochemistry, Molecular Biology, Bioengineering, or a related field. 4+ years of hands-on laboratory experience (academic or industry); relevant internship or research experience welcome. Familiarity with general molecular biology techniques (PCR, molecular cloning, gel electrophoresis). Exposure to antibody biology, display technologies (phage or yeast), and protein expression. Demonstrated ability to follow protocols carefully, troubleshoot experiments, and maintain detailed lab records. Effective time management and clear written and verbal communication skills. Collaborative, team-oriented mindset with an eagerness to learn in a fast-paced startup environment. Nice-to-haves include experience with flow cytometry, ELISA, or other binding assays, and familiarity with NGS or automation platforms. Total Rewards The salary estimated for this position is $120,000 - $135,000 +