VP, Digital Infrastructure and Operations

requirements of a global healthcare organization and public company. Lead disaster recovery, infrastructure resilience, and own availability strategies that ensure uninterrupted support for mission-critical business and laboratory operations, and partner with cross-functional leadership for enterprise business continuity. Build and develop an inclusive, high-performing global infrastructure organization through coaching, mentorship, succession planning, and a culture of continuous learning. Manage strategic technology investments, vendor partnerships, and infrastructure budgets with strong operational and financial discipline. What Success Looks Like During the first 12–24 months, this leader will: Establish a modern enterprise infrastructure strategy that supports Guardant's next phase of growth and innovation, with the ability to pivot for changes such as M&A integrations or implementation of emerging technologies. Accelerate infrastructure automation to improve operational efficiency, reduce manual effort, and increase service reliability. Embed AI-driven capabilities across infrastructure operations that augment engineering teams and enable smarter, faster decision-making. Improve infrastructure resilience, scalability, security, and employee experience through measurable operational improvements. Simplify technology architecture while reducing technical debt and increasing operational agility. Build an engaged, diverse, and high-performing infrastructure organization recognized as a trusted strategic partner across the business. Position the Digital Infrastructure team as an agile enabler of innovation, operational excellence, and Guardant's mission to transform cancer care. Lead change management and adoption across the technology org and enterprise as new solutions are deployed. What You'll Bring Leadership Executive leadership experience leading enterprise infrastructure organizations within high-growth biotechnology, life sciences, healthcare technology, medical diagnostics, or technology companies. A proven track record of leading enterprise transformation across complex, global organizations. Demonstrated success building inclusive, high-performing teams where diverse perspectives drive innovation, collaboration, and better business outcomes. Exceptional executive presence with the ability to influence senior leaders, communicate technical concepts to diverse audiences, and build trusted cross-functional partnerships. Relationship management skills across key stakeholders, including vendors, partners, auditors and regulators. Business ownership of a technology function – driving technical excellence while delivering measurable business value. Technology Experience across many of the following disciplines: Cloud Operations & FinOps (Azure, AWS) Network engineering Infrastructure engineering and operations Database engineering and operations Modern workplace technologies Identity and access management Collaboration platforms Self-service provisioning Infrastructure as Code Observability and operational intelligence Enterprise resilience and disaster recovery Hybrid architecture (cloud & on-prem/OT) Website performance and reliability at scale AI & Automation Mindset At Guardant Health, we believe AI has the potential to transform how enterprise technology teams operate. We're looking for a leader who has successfully leveraged AI to augment engineering teams, automate or eliminate repetitive work, improve operational intelligence, and accelerate technology delivery while maintaining the governance, security, and compliance expected within a regulated healthcare environment. Experience with generative AI, AIOps, enabling infrastructure for AI solutions (management and provisioning for agents, MCPs), predictive analytics, intelligent automation, workflow orchestration, productivity tools is highly desirable. Education and Experience Typically 15+ years of progressive experience leading enterprise infrastructure, platform engineering, cloud operations, or enterprise technology organizations, including executive leadership experience within complex global environments. Bachelor's degree in Computer Science, Information Systems, Engineering, or a related discipline, (or equivalent practical experience). Advanced degree preferred. Preferred Experience Experience supporting the unique demands of High Performance Computing (HPC) clusters, including compute, storage, networking, scalability, and performance optimization. While no single background is required, successful candidates will likely bring experience from one or more of the following industries: Biotechnology Precision Medicine Medical Diagnostics Genomics Healthcare Technology AI-first technology organizations Cloud-native software companies We also welcome leaders from innovative technology companies who have successfully modernized enterprise infrastructure through cloud transformation, platform engineering, automation, and AI-driven operations. Candidates should demonstrate operating at scale in a high growth environment, successfully transitioning through waves of expansion and infrastructure build-out. Experience of heterogeneous environments with enterprise, OT, on-prem and cloud under management. AI & Digital Fluency Demonstrate curiosity, sound judgment, and the ability to critically evaluate and responsibly leverage AI-enabled tools in accordance with company policies, ethical standards, and regulatory

requirements to improve the efficiency, effectiveness, and quality of work. Hybrid Work Model: This section is applicable to onsite employees who are eligible for hybrid work location as specified by management and related policies. Guardant has defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients. The annualized base salary ranges for the primary location and any additional locations are listed below. This range does not include

benefits or, if applicable,

bonus, commission, or equity. Each candidate’s

compensation offer will be based on multiple factors including, but not limited to, geography, experience, education, job-related skills, job duties, and business need. Primary Location: Palo Alto, CA Primary Location Base Pay Range: $288,100 - $396,150 Other US Location(s) Base Pay Range: $288,100 - $396,150 If

the role is performed in Colorado, the pay range for this job is: $288,100 - $396,150 Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time. Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to [email protected] A background screening including criminal history is required for this role. GH will consider qualified applicants with criminal arrest or conviction histories in a manner consistent with applicable law including but not limited to the LA County Fair Chance Policies and the Fair Chance Act (Gov. Code Section 12952). Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. All your information will be kept confidential according to EEO guidelines. To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants. Please visit our career page at: http://www.guardanthealth.com/jobs/ If you like wild growth and working with happy, enthusiastic over-achievers, you'll enjoy your career with us! Our Work Experience is the combination of everything that's unique

about us: our culture, our core values, our company meetings, our commitment to sustainability, our recognition programs, but most importantly, it's our people. Our employees are self-disciplined, hard working, curious, trustworthy, humble, and truthful. They make choices according to what is best for

the team, they live for opportunities to collaborate and make a difference, and they make us the #1 Top Workplace in the area. Join our Talent Community Don't miss an opportunity with Guardant Health. Be the first to hear about new roles, company news, and breakthroughs in the industry.

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