Vice President, Lifecycle Leader

requirements, and budget targets. Lead and develop the Lifecycle Leaders organization, providing strategic oversight and mentorship to lifecycle leads across Kyverna’s development portfolio. Establish best-in-class lifecycle governance, decision frameworks, and cross-program coordination processes. Partner with the Executive Leadership Team to ensure portfolio prioritization and investment decisions align with corporate strategy and value creation. Standardize lifecycle strategy development, program governance, and cross-functional planning across programs. Serve as a primary strategic advisor to executive leadership on program strategy, portfolio risk, and lifecycle opportunities. Lead preparation and presentation of program updates, strategic options, and decision packages to governance committees and the Board. Ensure robust risk assessment, scenario planning, and mitigation strategies are in place across the program. Define go/no-go decision points and guide governance discussions around program investment and strategic direction. Represent Kyverna externally with key scientific, regulatory, and industry stakeholders. Support strategic partnerships, collaborations, and licensing discussions where appropriate. Engage with key opinion leaders and external experts to inform program strategy. Ensure coordinated execution across all functional areas including: Clinical development Regulatory strategy CMC and manufacturing readiness Medical affairs and scientific communications Market access and commercial planning Oversee the development and execution of key program deliverables including: Integrated development strategies and plans Regulatory briefing documents IND/BLA/NDA supporting materials Clinical trial strategy Scientific publications and congress presentations

Qualifications PhD, MD, PharmD, MBA or equivalent advanced degree preferred. 15+ years of experience in biotechnology or pharmaceutical drug development, including significant leadership experience in clinical-stage programs. Demonstrated success leading complex global development programs from early development through late-stage clinical trials and regulatory filings. Experience serving as a program or lifecycle leader for a major therapeutic asset is required. Experience in Neuroimmunology is strongly preferred. Strong expertise in autoimmune disease, immunology, cell therapy, biologics, or related therapeutic areas strongly preferred. Deep understanding of the end-to-end drug development value chain, including research, translational science, clinical development, regulatory, manufacturing, and commercialization. Experience with global regulatory interactions and major submissions (IND, BLA, NDA). Demonstrated leadership in cross-functional matrix organizations and enterprise governance structures. Ability to interpret complex clinical and scientific data and translate insights into strategic decisions. Experience leading cross-functional teams in high-growth biotechnology environments. Strategic, enterprise-level thinker capable of driving portfolio-level impact. Strong executive presence and ability to influence senior leadership and Board stakeholders. Proven ability to lead high-performing cross-functional teams in complex, fast-moving environments. Strong judgment and decision-making skills in the face of uncertainty and evolving scientific data. Excellent communication and stakeholder management skills. \n The national salary range for this position is from $300K to $340K USD annually. This salary range is an estimate of what we reasonably expect to pay for this position, and the actual salary may vary based on various factors, including without limitation individual education, experience, tenure, skills and abilities, as well as internal equity and alignment with market data. This position is also eligible for

bonus,

benefits, and participation in Company’s stock plan.

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