About the role
Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. Position Summary: The Scientist 1, In Vitro role works closely with colleagues within the Biology, Chemistry, and Preclinical Development teams to evaluate new drug modalities by performing mechanistic studies and participate in discovery and translational efforts aimed at identifying and characterizing novel targeted therapeutic targets. This role works in a dynamic environment to help advance programs from discovery into development, as part of a multidisciplinary team. Essential Job Functions and
Responsibilities: These may include but are not limited to: Develop and maintain multiple cell lines independently. Implement excellent aseptic technique required for primary cell culture. Design, optimize, and validate pharmacology assays. Perform, analyze, and interpret assays independently. Maintain electronic laboratory notebooks in a timely and accurate manner. Write standard operating protocols. Participate in cross-functional drug discovery teams and interact with cross-functional groups effectively. Provide guidance and training to junior scientists. Interpret and present data and findings to cross-functional teams and leadership. Support the organization in maintaining a work environment focused on scientific integrity and quality, and one that fosters learning, open communication, collaboration, and teamwork. Other duties as assigned. Education and Experience: Required: Ph.D. in Biology, Behavioral Pharmacology, Physiology, Neuroscience, or related discipline with research experience in disease-related biology. Applicants with BS or MS degrees may apply but must demonstrate a minimum of 8 to 10 years of significant and relevant experience in pharmaceutical or life sciences industry. Strong cell culture expertise with proven experience in cell line development Experience with basic molecular biology techniques using DNA, RNA, and protein. Strong knowledge of molecular biology techniques to support cell line generation. Detail-oriented, with excellent organization and record-keeping skills. Capable of working both independently with minimal oversight and in a collaborative environment. Outstanding written and oral presentation capabilities, Software knowledge in Windows, MS Office (Outlook, Word, Excel, PowerPoint, SharePoint, Teams), GraphPad Prism, among others as required. Preferred: Experience in RNAi (siRNA, miRNA, ASOs) design and delivery. Experience in developing cancer, immunology, in vitro cell-based assays Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and