Senior Director, HR Operations Jobs at Cabaletta Bio Inc. Senior Director, HR Operations Philadelphia, PA Category: Human Resources Type: Full-time Min. Experience: Director Senior Director, HR Operations Philadelphia, Pennsylvania Cabaletta Bio (Nasdaq: CABA) is a clinical-stage biotechnology company focused on developing and launching the first curative targeted cell therapies designed specifically for patients with autoimmune diseases. The CABA™ platform encompasses two complementary strategies which aim to advance the discovery and development of engineered T cell therapies with the potential to become deep and durable, perhaps curative, treatments for a broad range of autoimmune diseases. The lead CARTA (Chimeric Antigen Receptor T cells for Autoimmunity) strategy is prioritizing the development of rese-cel, a 4-1BB-containing fully human CD19-CAR T cell investigational therapy. Rese-cel is currently being evaluated in the RESET™ (REstoring SElf-Tolerance) clinical development program spanning multiple therapeutic areas, including rheumatology, neurology and dermatology. The company recently presented final phase 1/2 data for rese-cel in myositis and expects to initiate the pivotal myositis trial this year. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, please visit www.cabalettabio.com and connect with us on LinkedIn. At Cabaletta, we are driven by the shared mission of developing cures, where a patient’s own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of
the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins
the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. And we’re proud that for 3 years in a row, we’ve been nationally recognized by Great Place to Work and Fortune as one of the Top 10 Best Small/Medium Workplaces in Biopharma! About the Position: The Senior Director, HR Operations is a strategic and execution‑focused leader responsible for building and scaling a modern, data‑driven HR infrastructure that enables organizational growth, operational excellence, and an exceptional employee experience. Reporting into the CHRO, this role will lead HR technology, global HR operations, compliance, and people analytics, while also serving as a trusted HR Business Partner for a few key business leaders.
The role will partner closely with Finance, Legal, and Business leadership to ensure that HR processes, systems, and insights are efficient, scalable, compliant, and aligned to business priorities, particularly in a dynamic, high‑growth environment. The ideal candidate brings a track record of implementing HR systems, automating operations, leveraging analytics for decision‑making, and partnering with executive leadership, along with experience supporting
compensation and
benefits programs.
Responsibilities: HR Operations and Technology Lead and optimize global HR operations across employee lifecycle processes (hire‑to‑retire), ensuring efficiency, scalability, and strong employee experience Design and implement standardized workflows, policies, and service delivery models to support growth, while driving continuous improvement, reducing manual processes and increasing operational effectiveness Own the implementation and optimization of HR systems (HCM, ATS, performance management tools, etc.), including integration and migration from a legacy PEO Partner with IT and business stakeholders to deliver scalable, user‑centric solutions Drive adoption of new systems, processes, and programs with high engagement and minimal disruption Leverage AI, automation, and digital tools to enhance HR service delivery, insights, and employee engagement People Analytics and Insights Establish and track metrics such as time‑to‑fill, productivity, retention, and diversity goals, providing real‑time visibility into headcount, attrition, engagement, performance, and hiring metrics Translate data into actionable insights that inform workforce planning, organizational design, and business decisions Support
Compensation planning cycles (merit,
bonus, equity) and Market benchmarking and job architecture Contribute to design and administration of competitive, scalable
benefits programs HR Business Partnering Serve as an HR partner to designated business leaders, providing guidance on organizational design, workforce planning, talent and performance management Support leaders with data‑driven insights and pragmatic solutions that balance speed, quality, and culture Act as a trusted advisor during periods of growth, transformation, or change, and lead operational readiness for rapid growth and organizational changes Support culture evolution through scalable HR practices that reinforce company values and performance expectations
Qualifications: Bachelor’s degree required; advanced degree (MHRM, MBA, or related) preferred. 15+ years of progressive HR experience, with focus in HR Operations and people analytics Demonstrated success leading HR technology implementations and transformations Experience building or scaling HR infrastructure in high‑growth or dynamic environments (biotech, tech, or similar industries preferred) Strong working knowledge of global HR compliance and employment practices Experience supporting
compensation processes and
benefits programs Track record of partnering with executive leaders and influencing decisions High level of judgment, adaptability, and resilience in fast‑paced environments Exceptional communication and stakeholder management skills Ability to operate effectively in a fast-paced, collaborative, and evolving environment. Our name – Cabaletta – is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, where the second act is designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression. For more information, please visit https://www.cabalettabio.com/join-our-crew Our most important asset is our people, and we offer competitive
