About the role
nChroma Bio is a clinical-stage genetic medicines company developing engineered epigenetic silencers to overcome the limitations of existing therapies and enable next-generation genomic medicines. By combining in vivo delivery and gene-regulating technologies, nChroma is designing optimal solutions to deliver precise, potent and durable treatments for patients with high unmet needs. nChroma’s lead candidate, CRMA-1001, is a clinical-stage, liver-directed epigenetic silencer in development as a potential functional cure for chronic hepatitis B. Guided by a world-class team at the forefront of genetic medicine, founded by renowned pioneers in the field, and supported by top-tier investors, nChroma is redefining targeted in vivo genetic medicine with the initial goal of treating diseases affecting the liver, blood, cardiovascular and central nervous systems. We’re building a culture and organization to support this important mission, bringing together individuals that thrive in a supportive environment where diverse perspectives and a passion for discovery drive cutting-edge science and breakthrough medicines.
ABOUT
THE ROLE The Analytical Development team is seeking a motivated and detail-oriented Research Associate to support advancement of the company’s LNP platform and ongoing clinical programs. The successful candidate will work closely with senior team members to support LNP process development, execute analytical testing for in vivo studies, and contribute to the characterization of LNPs as well as mRNA and gRNA payloads.
RESPONSIBILITIES Contribute to development of suitable biochemical and biophysical tools for characterizing LNPs containing RNA payloads used in epigenetic editing applications Optimize and troubleshoot existing analytical methods to improve accuracy, reliability, and sensitivity Collaborate with research and process development groups to routinely characterize products and process intermediates Contribute to design of experiments, analyze data, and document laboratory work in electronic lab notebooks Contribute ideas and present scientific findings at team meetings Assist with troubleshooting and regular maintenance of critical laboratory equipment and ordering of reagents and consumables SKILLS & COMPETENCIES: Hands-on experience with biophysical characterization of lipid nanoparticle formulations (e.g., SEC-MALS, AF4-MALS, DSC, cIEF, NTA, DLS, SAXS) and/or analysis and characterization of therapeutic nucleic acids (mRNA, oligonucleotides, plasmids) by chromatography (e.g., IPRP/IEX HPLC) and electrophoresis (e.g., CGE) required Experience with molecular and immunoassays (e.g., PCR, ELISA) is a plus Experience troubleshooting and optimizing routine analytical methods and experimental workflows, including instrumentation Working knowledge of data analysis and basic statistical approaches (e.g., quantification, trending) Strong organizational skills and attention to detail, with ability to manage multiple priorities in a fast-paced environment Strong communication skills and ability to work collaboratively within cross-functional teams Demonstrated curiosity and willingness to learn new techniques and support evolving project needs
