Principal Scientist, Medicinal Chemistry

JOB SUMMARY We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The ideal candidate will be passionate about solving medicinal chemistry challenges, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation. This position is on-site at our San Diego Headquarters. KEY

RESPONSIBILITIES Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles. Execute on high quality ideas by employing a broad range of modern organic chemistry transformations, synthetic methods, creative use of parallel experimentations and implementing innovative techniques. Work closely with molecular and cellular biology, pharmacology, computational chemistry, ADME, and other key functions Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation capabilities Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules Communicate project updates clearly and effectively to the broader team and key stakeholders Work as a member of the Chemistry research group and foster a culture of scientific excellence, innovation, and teamwork

QUALIFICATIONS BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry Experience in small molecule drug discovery in a biotechnology or pharmaceutical setting and a B.S. with 15+ years’ experience, M.S. with 12+ years’ experience or Ph.D. with 8+ years’ experience. Proven track record of success in advancing programs from leads to advanced candidates. Extensive experience in lead compound optimization for potency, selectivity, ADME and PK. Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents Practical experience and working knowledge of target protein degradation and associated modalities (molecular glues, PROTACS) Ability to integrate multiple R&D disciplines into a successful strategic project plan Experience working with computational chemists as part of project team in design of drug targets is required Strong interpersonal, communication, time management, and leadership skills Creative problem solving and management of relationships with several stakeholders within and beyond the company ABOUT IAMBIC THERAPEUTICS Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai . MISSION & CORE VALUES Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies. PAY AND