Job Application for Senior Scientist, Clinical Translational Medicine at Alpha-9 Oncology Back to jobs Senior Scientist, Clinical Translational Medicine Boston, Massachusetts, United States Apply Now Your Impact Alpha-9 Oncology is seeking a Lead/Senior Scientist in Translational Medicine to advance our radioligand therapy (RLT) programs through innovative biomarker and translational strategies. You will design, implement, and interpret translational assays using patient samples to guide clinical decision-making across early-phase studies, while providing scientific oversight to external vendors executing sample testing and assay workflows. This is a hands-on role where your expertise will directly impact the development of first-in-class RLT candidates, shaping Alpha-9’s translational science capabilities in a rapidly growing clinical-stage biotech. How You’ll Contribute Lead biomarker strategy and translational assay development for Alpha-9’s radioligand therapy (RLT) programs in solid and hematologic malignancies. Design, validate, and transfer tissue- and blood-based assays (e.g., multiplexed IHC, ligand-binding/ELISA, qPCR, flow cytometry, ctDNA) to support RLT clinical studies. Work with patient samples and provide scientific oversight of external CROs and laboratory vendors conducting translational testing to generate PK/PD, target engagement, exposure–response, and proof-of-mechanism data for RLT candidates. Collaborate cross-functionally with Clinical Development, Regulatory, and external partners to guide RLT study design, biomarker sampling strategy, and patient selection, incorporating imaging and radiopharmaceutical considerations. Author translational sections of clinical protocols, investigator brochures, and regulatory filings, incorporating RLT-specific biomarker strategies and radiopharmaceutical endpoints. Integrate advanced multiomic, spatial, and digital pathology approaches with radiation biology–related endpoints and dosimetry-informed analyses to drive actionable insights in early-phase RLT trials. The Skills You Bring Ph.D. in Oncology, Translational Medicine, Immunology, or related field with 5+ years of industry experience in biotech or pharma; 6+ years preferred. Experience leading translational biomarker strategy and assay development for oncology clinical programs, with radioligand therapy (RLT) and/or radiopharmaceutical experience strongly preferred. Hands-on expertise with tissue- and blood-based assays (e.g., multiplexed IHC, ELISA, qPCR, flow cytometry, ctDNA) and analyzing patient samples to generate PK/PD, target engagement, exposure–response, and proof-of-mechanism data. Experience providing scientific oversight of external CROs or laboratory vendors supporting patient sample testing and assay execution. Familiarity with RLT-specific translational considerations, including dosimetry principles, imaging-linked biomarkers, radiation biology endpoints, and radiopharmaceutical PK characteristics. Experience authoring translational sections of clinical protocols and regulatory documents, with knowledge of ICH/GCP
requirements for biomarker implementation. Strong cross-functional collaboration skills and ability to mentor junior scientists in a clinical-stage environment. Pay Transparency Statement Alpha-9 Oncology is committed to pay transparency and equitable
compensation practices.
Compensation for this position will align with the defined scope and
responsibilities of
the role and will take into account factors such as education, experience, and internal equity. In addition to base salary, this role is eligible for an annual performance
bonus, participation in our equity incentive plan, and a comprehensive
benefits package. The target salary range for this role is: $138,000 - $152,000 USD Company Summary Alpha-9 Oncology is a clinical-stage biotechnology company pioneering radiopharmaceutical innovation for solid tumors. Our proprietary scaffolds, composed of optimized binders, linkers, chelators, and radioisotopes, enable targeted radiation delivery to cancer cells, minimizing harm to surrounding healthy tissue. Focusing on innovative targeting moieties, we develop molecules tailored for precise tumor targeting. Our comprehensive platform integrates imaging and therapeutic studies to ensure effective radiation delivery and improved patient outcomes. With a robust pipeline entering clinical trials and strong support from leading healthcare investors, Alpha-9 is positioned for rapid growth and advancement in cancer therapy. More about Alpha-9 Oncology Alpha-9 Oncology is committed to fostering a diverse and inclusive workplace and is proud to be an Equal Opportunity Employer. We provide employment opportunities to all qualified applicants without regard to race, ethnicity, religion, age, sex, gender identity or expression, sexual orientation, disability, marital status, family status, national origin, or any other characteristic protected by applicable federal, provincial, or local laws where we operate. We are dedicated to providing reasonable accommodations to qualified applicants and employees to ensure that everyone can perform their essential job functions in an inclusive environment. For inquiries regarding accommodations in the hiring process or for current employees, please contact a member from our Talent Acquisition team. Create a Job Alert Interested in building your career at Alpha-9 Oncology? Get future opportunities sent straight to your email. Create alert Apply for this job * indicates a required field Autofill with MyGreenhouse First Name * Last Name * Email * Phone Country * Phone * Resume/CV * Attach Attach Dropbox Google Drive Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Cover Letter Attach Attach Dropbox Google Drive Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Education School * Select... Degree * Select... Add another Address Line 1 * Street Address Address Line 2 Street Address continued City * The city in which you reside State * Select... The State within the United States in which you reside Postal Code * Are you legally authorized to work in the United States? * Select... Do you now or will you in the future require sponsorship to work in the U.S.? (e.g., H-1B visa status)? * Select... Are you able to work in the specified job location, or are you willing to relocate for this position? * What date would you be available to start in this position? * How did you hear about this job? * Select... If other, please share source LinkedIn Profile Submit application Powered by Greenhouse
Salary
$138,000 - $152,000
Location
Boston, Massachusetts, United States
Experience
6+ years
Total raised
$261
Last stage
Growth
Investors
David Perrin
PhD
Kuo-Shyan Lin
PhD
François Bénard
MD
No applications, no recruiter spam. Just the intro.
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