About the role
About Mandolin Nearly every disease will become treatable in our lifetimes. Mandolin is laying the clinical and financial infrastructure to get groundbreaking treatments to patients faster, powered by AI agents. Mandolin partners closely with the largest healthcare institutions in the US, covering more than $10B drug spend across the country. We're backed by Greylock, SV Angel, Maverick, SignalFire, and the founders of Vercel, Decagon, and Yahoo.
The Role Mandolin is seeking a highly motivated and versatile Security Engineer to help secure our applications, cloud infrastructure, and compliance programs. This role is ideal for a security generalist with hands-on experience across Application Security, Platform/Cloud Security, and Governance, Risk & Compliance (GRC). The ideal candidate will partner closely with Engineering, DevOps, IT, and Compliance teams to embed security into software development, infrastructure, and operational processes while supporting the organization’s overall security and compliance posture. The ideal candidate is a hands-on security professional who can operate across multiple security domains, balance technical and compliance priorities, and help build scalable, practical, and business-aligned security programs. What you’ll do Integrate security into the Software Development Lifecycle (SDLC) and CI/CD pipelines Conduct application security reviews, threat modeling, vulnerability assessments, and support secure code review practices Identify and remediate vulnerabilities related to the OWASP Top 10, APIs, authentication/authorization, secrets management, and software dependencies Design and implement security controls across cloud and infrastructure environments including AWS, Azure, or GCP Secure cloud-native platforms, containers, Kubernetes environments, CI/CD systems, and Infrastructure-as-Code (IaC) deployments Monitor and improve logging, alerting, vulnerability management, endpoint protection, and incident response capabilities Collaborate with Platform Engineering and DevOps teams to improve infrastructure hardening and operational security practices Support security compliance initiatives including SOC 2, ISO 27001, HIPAA, PCI-DSS, GDPR, and NIST-based programs Assist with risk assessments, audit readiness, evidence collection, policy development, vendor security reviews, and remediation tracking Help drive security awareness, promote secure engineering best practices, and contribute to long-term security strategy and maturity initiatives Research emerging threats, vulnerabilities, and security technologies to continuously improve organizational security posture Must-have experience 4+ years of experience in Security Engineering, Application Security, Cloud Security, DevSecOps, or related cybersecurity roles Strong understanding of application security, infrastructure/cloud security, and security compliance concepts Experience securing modern web applications, APIs, cloud environments, and distributed systems Hands-on experience with cloud platforms such as AWS, Azure, or GCP Familiarity with CI/CD pipelines, container security, Kubernetes, and Infrastructure-as-Code security practices Experience with security tools such as SAST, DAST, SIEM, vulnerability scanners, CSPM, EDR/XDR, and IAM solutions Scripting or automation experience using Python, Bash, PowerShell, or similar languages. Strong communication skills with the ability to collaborate across technical and non-technical teams Nice-to-haves Experience in SaaS, fintech, healthcare, or other regulated environments Familiarity with Zero Trust architectures and modern identity/security frameworks Experience supporting compliance audits and governance initiatives Relevant certifications such as CISSP, Security+, CCSP, AWS Security Specialty, GSEC, OSCP, or similar