About the role
Position: Research Associate II, Platform Location: Cambridge, MA Job Id: 308 # of Openings: 1 Position Title: Research Associate II, Platform Reports To: Principal Scientist Location: Cambridge, MA Join the adventure! CAMP4 is leveraging a proprietary drug discovery platform to discover antisense oligonucleotides (ASOs) targeting regulatory RNAs to treat a broad range of central nervous system diseases. We are seeking a passionate Research Associate II to join the Platform team responsible for high-throughput screening, regRNA target identification and characterization, as well as development of innovative strategies and experimental and computational approaches for optimization of ASO therapeutics targeting regulatory RNAs. You will work closely with the Discovery, Chemistry, Data Science, and Preclinical teams to advance the research of transcriptional mechanisms mediated by regRNAs and the development of therapeutic candidates for programs across multiple therapeutic areas. A successful candidate will apply their experience in tissue processing, including RNA and protein extraction and quantification, to characterize the effects of candidate ASOs on target engagement and phenotypic rescue. This is an exciting opportunity for a highly creative, scientifically curious, self-motivated, and collaborative individual with excellent organizational and communication skills. Key
Responsibilities: Design and conduct targeted RNA sequencing including probe-based target enrichment, library preparation, and long read sequencing. Assist with genomic mapping of various cell and tissue systems including sterile cell culture, processing, cell fractionation, and library generation. Investigate transcriptional mechanisms of action for pre-clinical candidates for a variety of therapeutic areas using reverse genetics, functional genomics, and systems biology approaches. Analyze, interpret, and present data to internal and external experts. Maintain detailed records of experimental designs and results. Support daily laboratory operations and maintenance including ordering and preparation of reagents and supplies, equipment maintenance, and other housekeeping activities. Demonstrate an exceptional work ethic by taking initiative and working with a sense of urgency to discover breakthrough medicines that will improve patients’ lives; collaborate and share ideas with the rest of the CAMP4 team.